Correction: Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom
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چکیده
1524 October 2008 | Volume 5 | Issue 10 | e209 Correction: Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom Simon C. Wagstaff, Gavin D. Laing, R. David G. Theakston, Christina Papaspyridis, Robert A. Harrison Correction for: Wagstaff SC, Laing GD, Theakston RDG, Papaspyridis C, Harrison RA (2006) Bioinformatics and multiepitope DNA immunization to design rational snake antivenom. PLoS Med 3(6): e184. doi:10.1371/journal.pmed.0030184 In the Supporting Information section of this paper, Figure S1 and Figure S2 were incorrectly linked. Figure S1 and Figure S2 labeled and in the order originally intended are provided here. Figure S1. Comparative Sequence Analysis of Full-Length PI-PIII SVMP Isoforms Found at doi:10.1371/journal.pmed.0050209.sg001 (48 KB PDF). Figure S2. Composition of the E. ocellatus Venom Gland Transcriptome Found at doi:10.1371/journal.pmed.0050209.sg002 (32 KB PDF). Citation: Wagstaff SC, Laing GD, Theakston RDG, Papaspyridis C, Harrison RA (2008) Correction: Bioinformatics and multiepitope DNA immunization to design rational snake antivenom. PLoS Med 5(10): e209. doi:10.1371/journal. pmed.0050209
منابع مشابه
Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom
BACKGROUND Snake venom is a potentially lethal and complex mixture of hundreds of functionally diverse proteins that are difficult to purify and hence difficult to characterize. These difficulties have inhibited the development of toxin-targeted therapy, and conventional antivenom is still generated from the sera of horses or sheep immunized with whole venom. Although life-saving, antivenoms co...
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BACKGROUND Envenoming by coral snakes (Elapidae: Micrurus), although not abundant, represent a serious health threat in the Americas, especially because antivenoms are scarce. The development of adequate amounts of antielapidic serum for the treatment of accidents caused by snakes like Micrurus corallinus is a challenging task due to characteristics such as low venom yield, fossorial habit, rel...
متن کاملProgress and improvement of the manufacturing process of snake antivenom
Antivenoms have been used successfully for more than a century and up to now constitute the only effective treatment for snakebites .The production of antivenin started long time ago when the calmette was prepared the antivenom in 1894.The method currently used to prepare antivenom by most of the manufacturers are originated from the method of Pope which was develop in 1938. Several new approac...
متن کاملPrognosis of Hepatic Amyloidosis Status and Insufficiency in Snake Antivenom Producing Horses
Hyperimmunization of horses with specific antigens to harvest antisera is associated with high incidence of liver amyloidosis. The histopathologic examination is the gold standard method for diagnosis of the hepatic amyloidosis. The aim of the present study was to determine whether the clinical manifestations and serum values of appropriate chemical constituents due to liver injury, provide the...
متن کاملBioinformatics-based design of novel antigenic B-cell linear epitopes of Deinagkistrodon acutus venom.
OBJECTIVE With the help of bioinformatics analysis, we wished to develop a novel antivenom against the Deinagkistrodon (D.) acutus snake venom using B-cell linear epitopes of three primary toxins (serine protease, metalloprotease, and phospholipase A2). MATERIALS AND METHODS cDNA sequences of three toxins of D. acutus venom were retrieved from the NCBI database. B-cell linear epitopes were pr...
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عنوان ژورنال:
- PLoS Medicine
دوره 5 شماره
صفحات -
تاریخ انتشار 2008